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1996-03-09
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Document 0533
DOCN M9650533
TI Efficacy of ultraviolet B phototherapy for psoriasis in patients
infected with human immunodeficiency virus.
DT 9605
AU Fotiades J; Lim HW; Jiang SB; Soter NA; Sanchez M; Moy J; Ronald O.
Perelman Department of Dermatology, New York University; School of
Medicine, NY 10016, USA.
SO Photodermatol Photoimmunol Photomed. 1995 Jun;11(3):107-11. Unique
Identifier : AIDSLINE MED/96139930
AB To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the
treatment of psoriasis in patients infected with human immunodeficiency
virus (HIV), the response of 14 patients was compared to that of matched
seronegative control individuals. All patients were evaluated prior to
treatment (baseline) and after 21 treatments for the extent of total
body surface area (TBSA) involvement and the quantification of scale,
erythema, and thickness of plaques using a scale of 0 (absent) to 4
(severe). The only concomitant medication allowed was salicylic acid in
petrolatum. The cumulative score for scale, erythema, and thickness
improved 1.9 +/- 0.5 [mean +/- standard error of mean (SEM)] in the HIV
group and 2.4 +/- 0.3 in controls. There was 40.9 +/- 7.3% reduction of
TBSA involvement in the former and 38.4 +/- 7.6% reduction in the latter
group. None of the differences was statistically significant. There was
no statistically significant difference in the response to therapy among
various stages of immunosuppression in the HIV group. There was also no
deterioration of immune status in this group. UVB phototherapy is an
effective treatment for psoriasis in patients infected with HIV. The
response is identical to that of matched control individuals.
DE Administration, Cutaneous Adult Antiviral Agents/THERAPEUTIC USE Body
Surface Area Case-Control Studies Comparative Study CD4 Lymphocyte
Count Dermatitis, Exfoliative/COMPLICATIONS/PATHOLOGY/RADIOTHERAPY
Erythema/PATHOLOGY Human *HIV Infections/COMPLICATIONS/DRUG
THERAPY/IMMUNOLOGY HIV Seronegativity Immunocompromised Host
Keratolytic Agents/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Male
Psoriasis/COMPLICATIONS/IMMUNOLOGY/PATHOLOGY/*RADIOTHERAPY Salicylic
Acids/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Ultraviolet
Rays/CLASSIFICATION Ultraviolet Therapy/*METHODS
Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).